Amgen cholesterol drug cuts heart attack, stroke risk but shares fall

21 March, 2017, 00:48 | Author: Lorraine Moran

Experts said the findings were the most important since the first statins trials two decades ago.

Analysts at Jefferies also think TMC's management can draw on those datasets for the design of ORION-4, which they suggest would likely involve 10-14,000 patients, have a two-year-plus follow-up and could-potentially-show a 30% reduction in cardiovascular events.

Amgen's FOURIER study enrolled 27,564 patients with a prior medical history of heart attack, stroke or other coronary artery disease.

"The magnitude of benefit on heart attacks and strokes are about what thoughtful people would have expected", he said, adding that he did not expect a death benefit after just 26 months. The implication, he said, is that larger benefit is "probably a true reflection of what patients will experience if they take the drug over time".

Millions of people consume drugs called statins to minimize the amount of bad cholesterol.

A powerful cholesterol drug cuts the risk of heart attacks by a quarter, a landmark trial has found.

Amgen and Sanofi/Regeneron have been hoping that new data showing that reductions in LDL cholesterol (LDL-c) are mirrored by significant reductions in the cardiovascular complications of high cholesterol will drive uptake, and Amgen reported the results of its outcomes trial-Fourier-at the American College of Cardiology (ACC) meeting over the weekend. The man-made antibody helps in cutting down the risk of cardiovascular and heart diseases related death in people by 20%.

In the study, published today in the New England Journal of Medicine, researchers looked at the protective effect of evolocumab on patients in 49 countries, with a history of atherosclerotic vascular disease, who were already taking statins to reduce their cholesterol.

Repatha shots are given once or twice in a month while patients take statins regularly. The benefit grew with longer use, and was 25 percent the second year, said Sabatine, who consults for Amgen and other drugmakers.

Arnold Palmer Invitational: Tyrrell Hatton & Matthew Fitzpatrick three shots off lead
Following a second-round 66 for a one-shot lead on Emiliano Grillo, Hoffman found bunkers to bogey the first two holes. That sixth hole has gotten a ton of notoriety this week, what with Cody Gribble's closeup with a lounging gator.

NCAA Tournament 2017: Kent State exits, but not quietly vs. UCLA
The last time Kansas lost an opening-round game of the NCAA Tournament was as a No. 4 seed in 2006 to a Bradley team led by Les. This season Caupain is No. 5 in country in assist turnover ratio, according to the NCAA's official site.

Family of Trump son-in-law in $4 bn deal with Chinese company
The talks for this deal had started a year ago when Jared Kushner had met Wu Xiaohui, the chairman of Anbang Insurance Group. Technology firm 1WorldSync has reached a deal to lease 22,247 square feet at 300 S.

Amgen said today it would offer a refund to payers that "lower access barriers" if patients on their plans taking evolocumab suffer a heart attack or stroke.

Yet Repatha's high cost could burden the US health system, said Dr. Steve Miller, senior vice president and chief medical officer at Express Scripts, a pharmacy benefit manager.

Fuster also noted that in absolute numbers, the drug saved about two percent of lives.

Evolocumab is a fully human monoclonal antibody that works by blocking proprotein convertase subtilisin-kexin 9 (PCSK) - a protein that reduces the liver's ability to remove LDL cholesterol from the blood.

The cost varies, but it is thought to cost the UK's NHS about £2,000 per year per patient where it is already being given to people who do not respond to statins. The fresh evidence could mean many more patients become eligible.

But it comes at a hefty price tag of more than $14,000 per year, raising concerns about how many patients could benefit. But in the Mizuho Securities conference call, participants agreed that a reasonable estimate of the direct hospital cost of treating a stroke is around $20,000 to $40,000, while the total lifetime costs are about $100,000 for an elderly patient, and up to $500,000 for a young patient.

"It sounds like the patient gets harmed and the payer has its financial risk reduced", said cardiologist Cam Patterson, chief operating officer at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, who wasn't involved in the study.

Prof Sir Nilesh Samani, medical director at the British Heart Foundation, said: "Coronary heart disease is the single biggest killer in the United Kingdom and worldwide and "bad" LDL-cholesterol is a major cause".


  • Mass Effect Andromeda Review: Title Slammed Over Facial & Scenery Graphics

    Mass Effect Andromeda Review: Title Slammed Over Facial & Scenery Graphics

    BioWare's Ian Frazier was taking questions on Twitter from fans about the game when he was asked about the animations. Most , if not all, reports said that the issue is so bad that it affects the gameplay experience for every player.
    Nintendo Switch Has Six Month Old Bugs, Device Vulnerable To Hackers

    Nintendo Switch Has Six Month Old Bugs, Device Vulnerable To Hackers

    After all, the Wii U sold around 3 million units in its first 6 weeks, but went on to sell just 13.5 million units total. In total, Nintendo is apparently aiming to have produced 16 million Switch consoles by the end of March 2018.

    Woman Jumps Out of Trunk to Escape Kidnapper in Birmingham, Alabama

    Alsabah told that the woman grabbed his shotgun before he took it away, assuring her that she was safe. The suspect forced her into the back of her vehicle after she told him she didn't have any money.
  • Calcutta High Court orders CBI enquiry into Narada sting tapes

    Calcutta High Court orders CBI enquiry into Narada sting tapes

    From the beginning, TMC leadership has claimed that the sting footage was doctored and a conspiracy of oppositions. The bench also termed the state police as puppet and said that the society demands proper probe on the matter.
    'Bachelorette' Rachel Surprised by First Four Men After 'Bachelor' Finale

    'Bachelorette' Rachel Surprised by First Four Men After 'Bachelor' Finale

    As for how these first four men stack up against other candidates this season, Realty Steve says viewers shouldn't expect much. Guy number two, Blake , exchanged an awkward hug and kiss on the cheek with the leading lady.
    Trump's Revised Travel Ban Denounced by Over 130 Experts

    Trump's Revised Travel Ban Denounced by Over 130 Experts

    Watson pointedly asked: "How do we assess that the neutrality (of the new order's text) isn't a subterfuge in some way?" U.S. District Judge James Robart will hear arguments Wednesday in the lawsuit brought by the Northwest Immigrant Rights Project.
  • Monaco fear no one after eliminating Manchester City

    Monaco fear no one after eliminating Manchester City

    Second half [City] missed chance after chance. "A lot of people thought we could not go through (after the first leg) but we are a great team".

    Dollar steadies after worst fall in two months

    CURRENCIES: The euro from dipped to $1.0746 from $1.0749 late Thursday, and the British pound fell to $1.2367 from $1.2358. But the dollar struggled to make more progress through the European morning and waned as NY traders arrived at their desks.
    Viral video dad breaks silence on 'comedy of errors' clip

    Viral video dad breaks silence on 'comedy of errors' clip

    Then, their lives changed nearly immediately, and they had to put their phones on airplane mode because of all the demand. Kelly's wife Jung-a Kim , whose mad dash into the room was nothing short of heroic, said they "laughed a lot" afterwards.
  • Stephen Colbert Hilariously Parodies Rachel Maddow's Trump Tax Return Reveal

    The MSNBC host had held forth for nearly half an hour before revealing that she had the first two pages of Trump's 2005 Form 1040. Stephen Colbert mocked MSNBC host Rachel Maddow's long-drawn out reveal of Donald Trump's tax returns this week.
    Making 'Ayogya' Yogi UP CM is BJP's biggest mistake: Tejaswi Yadav

    Making 'Ayogya' Yogi UP CM is BJP's biggest mistake: Tejaswi Yadav

    Yogi's father Anand Singh Bisht is flying tomorrow to Lucknow for attending the swearing in ceremony of the new Uttar Pradesh CM. While the BJP MP has largely focused on Hindutva, one can not overlook his contributions to the development cause either.
    Trump attacks media again, calls meeting with Merkel 'GREAT'

    Trump attacks media again, calls meeting with Merkel 'GREAT'

    Trump was also asked point-blank by one reporter why he keeps making statements he knows are not true. He repeated those claims with Ms.


Federer beats Wawrinka for fifth Indian Wells title
Wawrinka started to take control of the match in the sixth game, when he reached a break point for the first time in the match. Roger Federer became the oldest player to win a Game Slam title since 1972 when he won the Australian Open in January.

Syrian army fires at Israeli warplanes
A Jordanian military source said shrapnel from one missile fell in the north of the kingdom without causing any casualties. The Israeli military said its planes were already back in Israeli airspace when the SAMs were fired.

Kevin Keatts hired by NC State
North Carolina State will hire UNC Wilmington's Kevin Keatts as its men's basketball coach, according to multiple reports Friday. Things were going pretty well, even though Gottfried's teams didn't get any farther than the Sweet Sixteen.

Congressman demands to know whether Trump knew Flynn took Russian Federation money
Last week, it was revealed that Flynn also was lobbying for a Turkish firm late a year ago , earning $530,000. The findings were contained in the community's report about Russia's attempt to influence the U.S. election.

USMNT roster for March World Cup qualifiers announced
The 34-year-old striker was cleared to play in January, however, and started both of Seattle's first two games this season. Jones has six goals in 59 career appearances, including four in 2018 FIFA World Cup Qualifiers.

'Now not the time' for independence vote
Next week, MSPs are due to debate a request for a Section 30 order to transfer power for the vote to the Scottish Parliament . May added: "I say to the SNP, now is not the time ".

'Big Bang Theory' spinoff, 'Young Sheldon,' ordered by CBS
Young Sheldon , while being a spinoff of the Big Bang Theory , includes a number of veterans from the original show. Variety adds that the pilot script was written by "The Big Bang Theory" showrunner Steven Molaro .

Emperor receives Saudi king at Imperial Palace in Tokyo
After leaving Tokyo , the king is to lead his entourage of more than 1,000 cabinet members and corporate executives on to China. Retno added that in the next two months, the President would he send a minister to follow up King Salman's visit to Indonesia.

Saints trade WR Cooks to Patriots for draft picks
In the end, Butler could be on his way out, but could find that big pay check that he has been looking for. A large contingent of New England Patriots fans might soon be very let down and very vocal.

Pres. Trump on White House Intruder: 'It Was a Troubled Person'
He had the mace in a jacket pocket and a book bag with a book on the President, a USA passport and an Apple laptop computer. In 2014 a man made it past eight Secret Service agents with a three-and-a-half-inch folding knife in his trouser pocket.